Spatial Biology

By combining molecular profiling with spatial information, researchers can investigate gene expression, protein abundance and regulatory mechanisms while preserving the architecture of the tissue. At the South Australian Genomics Centre (SAGC), we provide access to a comprehensive portfolio of spatial technologies, supporting everything from whole-transcriptome discovery to high-resolution cellular imaging and spatial multiomics.Whether you're exploring tissue heterogeneity, investigating cellular interactions or scaling up to larger spatial studies, our team can help you identify the right approach for your research.

Planning Your Spatial Experiment

Finding the right spatial technology for your research

With a range of spatial technologies available, selecting the right approach can be challenging. Each platform offers different advantages in molecular coverage, spatial resolution, tissue compatibility and scalability. At SAGC, our team works with researchers to design spatial experiments around their biological questions, sample types and study objectives. Whether you're undertaking exploratory discovery, validating specific molecular targets or investigating larger sample cohorts, there are several important factors to consider.

Explore your experimental requirements

Interactive experiment planning guide

What do you want to measure?

RNA expression

Proteins

Chromatin accessibility / epigenetics

Multiple molecular layers

Are you exploring or testing a hypothesis?

Discovery / whole transcriptome

Targeted gene panels

Both

What type of tissue do you have?

Fresh frozen

FFPE / archived tissue

Not yet collected

What species?

Human

Mouse

Other

How many samples are you planning?

Pilot / feasibility study

Small comparative study

Large cohort / time course

High-Throughput Spatial Transcriptomics

Scale spatial studies with Stereo-seq, including fresh-frozen and FFPE workflows, and the automated sample processing using Go Spatial.

Explore Stereo-seq and automation

Spatial Proteomics and Multiomics

Explore protein expression, cell phenotypes and molecular interactions in their native tissue environment, including approaches that combine spatial RNA and protein analysis.

Explore spatial proteomics & multiomics

Spatial Epigenomics

Investigate spatial patterns of chromatin accessibility, DNA methylation and gene regulation to understand how epigenetic states contribute to tissue organisation and cellular identity

COMING SOON! - Register your interest

From Tissue to Insight

End-to-End Spatial Biology Services

Successful spatial experiments require more than choosing the right technology. From sample preparation and tissue handling through to molecular profiling and downstream analysis, SAGC supports researchers across the entire spatial biology workflow.

Study design
Tissue prep
Spatial profiling
Data analysis
Biological insight

Working with our histology partners, we can assist with tissue QC/sectioning, running the spatial assay, NGS when required, spatial analysis pipelines (both manufacturer and 3^rd party tools). Our team can also help researchers evaluate the opportunities for integrating spatial data with single-cell genomics and other molecular datasets.

Spatial Biology

Spatial biology is transforming our understanding of how cells interact, organise and function within complex tissues.

EXPLORE OUR SPATIAL PLATFORMS

Xenium In Situ

CosMx SMI

Visium HD

Stereo-seq^TM

Whole-transcriptome spatial profiling at scale

EXPLORE OUR SPATIAL PLATFORMS

Targeted, subcellular-resolution imaging.

High-resolution transcriptome-wide discovery.

Whole-transcriptome spatial profiling at scale.

Planning Your Spatial Experiment

Finding the right spatial technology for your research

Interactive experiment planning guide

View our Spatial Planning Guide