Spatial Transcriptomics
Spatial transcriptomics is the study of gene expression patterns within the context of tissue architecture and can provide a more complete understanding of cell-cell interactions. It is a powerful tool for anyone interested in understanding the complexity of biological systems and tissue organization at high resolution.
Our Spatial Multiomics Platforms
Off-the-shelf (up to 5K)
Custom Panels
Protein Sub-Panel Add-ons
Single cell spatial imaging with 10x Genomics Xenium Analyser
We offer end-to-end Xenium service at competitive pricing, including:
- Sub-cellular resolution of individual transcripts
- Easy and intuitive tissue-scale comparisons
- Seamless panning, zooming, and analysis of your entire tissue section
- Off-the-shelf gene panels (100's to 1000's RNAs) and add-on Protein panels
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Visium & Visium HD
Visium HD WT Panel (Human, Mouse, or Custom)
- Specialised slides contain spatially barcoded spots giving you high-resolution from standard tissue sectioning and staining.
- Compatible with FFPE and fresh frozen (FF) tissue samples.
- Whole transcriptome analysis – no need to select targets or specific region of interest.
- CytAssist enabled to allow transfer of tissues from archived slides.
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NEW Visium HD 3’ Poly A (FF only)
- Species agnostic (enables plants and non-model organisms)
- Potential for TCR & BCR sequencing
Stereo-seq (SpaTial Enhanced Resolution Omics-Sequencing)
Whole transcriptomics for discovery applications (range of 1000-2000 genes/cell) leverages in situ mRNA capture and cDNA sequencing with barcoded spatial coordinates to create a spatial transcriptomic profile of the tissue section:
- Subcellular spatial localisation of mRNA
- Species agnostic
- Spot size = 200 nm diameter
- Range of field size to accommodate larger tissue samples (up to 13 cm x 13cm)
STOmics Stereo-seq OMNI for FFPE Samples
- Total RNA and Microbial RNA
- Enables Host Pathogen Detection
- Species Agnostic
- Single-cell Resolution
Xenium In Situ
Targeted gene expression and protein quantification at subcellular resolution
Xenium is an end-to-end platform that enables high-throughput subcellular mapping of RNA targets.
- Menu of off-the-shelf gene panels (up to 5K) and add your custom gene targets using free panel designer
- Compatible with fresh frozen (FF) and formalin-fixed, paraffin-embedded (FFPE) tissues
- Microscopy based read-out (no NGS), allows H&E post-run
- Single molecule RNA and Protein targets (subcellular resolution)
CosMx SMI
Imaging-based in situ analysis platform delivering spatial multiomic profiling from FFPE and FF samples to subcellular resolution.
- High-plex RNA panels: quantification and visualisation of 3 sizes of human RNA panels; 1K, 6K, 19K WTX (human whole transcriptome, mouse WTX available soon).
- Standalone protein or same-slide add-onto RNA assays for multiomic analyses.
- CosMx v2.0 upgrade delivers 1.5 to 2x sensitivity increases and best in class cell segmentation.
