The South Australian Genomics Centre (SAGC) has expanded its epigenomics capabilities with the introduction of Watchmaker Genomics TAPS+ whole-genome methylation sequencing, providing researchers with a new approach to studying DNA methylation and genetic variation together at whole-genome scale at approximately 30% lower cost than comparable 5-base whole-genome approaches.
DNA methylation adds an important layer of information beyond the four bases of the genome. By measuring A, T, G, C and 5mC, 5-base sequencing can provide an integrated view of genetic variation and DNA methylation across the genome.
The Watchmaker DNA Library Prep Kit with TAPS+ (distributed by TrendBio in Australia) uses a positive-readout approach that converts methylated cytosines while preserving unmethylated cytosines.
By retaining much more of the native four-base sequence complexity, TAPS+ supports efficient genome alignment and enables genomic variant analysis alongside genome-wide methylation detection.
From the same library, researchers can investigate:
This dual-omics approach is particularly valuable for studies seeking to understand how variation in the underlying genome interacts with epigenetic regulation